5.1-Frasier's Imaginary Friend-It is continued from Season 4 Ender, Odd Man Out. Frasier gets a hold of Laura, but learns some news about her.
5.2-The Gift Horse-Martin's 65th birthday is being held. Niles, Frasier, Daphne, and Sherry give Martin different gifts.
5.3-Halloween-Niles hosts a literary-themed Halloween party. Roz thinks she pregnant.
5.4-The Kid-Roz is embarrassed of what happened at the party a couple of days ago. Roz finds a younger boy who wants to marry her.
5.5-The 1000th Show-"Frasier Crane Day" is being held at Seattle and Frasier is being detained for various reasons.
5.6-Voyage of the Damned-Roz, Niles, Martin, and Frasier are all on a cruise. Niles knows Maris is somewhere on this ship, also.
5.7-My Fair Frasier-Frasier meets Samantha, a high-profile criminal defense attorney, while returning an unwanted gift for Roz.
5.8-Desperately Seeking Closure-Frasier likes to spend time with Sam whenever he can.
5.9-Perspectives On Christmas-Martin, Daphne, Niles, and Roz recall previous memories on Christmas.
5.10-Where Every Bloke Knows Your Name-Frasier goes with Daphne to a bar which Daphne likes, but Daphne soon regrets taking him along.
5.11-Ain't Nobody's Business If I Do-Daphne finds an engagement in one of Martin's draws for Sherry.
5.12-The Zoo Story-Frasier is torn apart a choice between Bebe Glazer or his current representative, Ben.
5.13-The Maris Counselor-Niles starts to think that his couples therapist is having an affair with Maris.
5.14-The Ski Lodge-Roz wins a free trip to a ski lodge, but traded them with Frasier for a Big Screen TV.
5.15-Room Service-Lilith comes to Seattle to tell Frasier that her husband left her for someone else.
5.16-Beware of Greeks-Nikos Crane, Frasier's half-Greek cousin, drops in Seattle to tell Frasier and Niles that she is getting married.
5.17-The Perfect Guy-There is a new doctor show at KACL 780AM. Roz is attracted to Dr. Clint Webber, the new personality. Bulldog learns that every lady at KACL likes him, and dislikes it.
5.18-Bad Dog-There is a conflict with whether Bulldog hid behind a pregnant Roz or stood in front for protection.
5.19-Frasier Gotta Have It-Frasier dates Caitlin, but soon realizes that they have nothing in common.
5.20-First Date-Niles keeps feeling queasy when he tries to ask Daphne out for a date.
5.21-Roz and the Schnoz-Roz meets Rick's parents which have a quite distracting feature on their faces.
5.22-The Life of The Party-At a party, Frasier and Niles compete over the same woman. Roz's water breaks in the middle of the party and is rushed to hospital. She has a baby, Alice May Doyle.
5.23-Frasier keeps being late to meet Tricia, a lady he met at the opera.
5.24-Sweet Dreams-Kenny Daly is the new KACL manager. Some of the staff rise up to confront Mr. Martin, the station owner, about the sponsor's advert. Mr. Martin turns back on them and changes the station to an all Latino music station, leaving all the on-air talent out of a job.